Corrigendum. Non-invasive pre-implantation genetic testing of human embryos: an emerging concept

Epithelial cadherin distribution in abnormal human pre-implantation embryos.

BACKGROUND E(epithelial)-cadherin is a vital cell adhesion protein that plays a critical role in morphogenesis. Previous studies of E-cadherin distribution in human embryos have produced equivocal results. METHODS Immunocytochemistry in conjunction with laser scanning confocal microscopy was used to detect E-cadherin in 97 human cleavage stage embryos and 35 blastocysts from normal and abnorm...

Melatonin upregulates ErbB1 and ErbB4, two primary implantation receptors, in pre-implantation mouse embryos

Objective(s): To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). Materials and Methods: Two-cell mouse embryos were cultured in 3 groups: simple media, melatonin-treated (10-9 M melatonin) and Luzindole-treated (10-9 M luzindole). Then, the rate of ErbB1 and ErbB4 gene and protein expression, the leve...

Pre-implantation genetic diagnosis.

Pre-implantation genetic diagnosis (PGD) was first pioneered at Hammersmith Hospital, London, United Kingdom, in 1989 and allows the genetic sampling and testing of the early human embryo prior to being transferred to the uterus to start a pregnancy. Although occasionally controversial, PGD is now well established in several countries and in vitro fertilisation (IVF) centres around the world. I...

Pre-implantation genetic diagnosis.book

Pre-implantation genetic diagnosis (PGD) is the examination in vitro of an embryo (or an egg cell prior to fertilisation) in order to exclude a genetic condition in case a very high risk of that condition is known. PGD can only be used in combination with in vitro fertilisation (IVF). If a genetic abnormality in the form of a monogenetic disease such as Huntington’s disease or cystic fibrosis o...

Pre-implantation genetic diagnosis.book